Unstructured Region-mediated Substrate Recognition by the Proteasome
نویسندگان
چکیده
منابع مشابه
Proteasome degradation: enter the substrate.
Cells depend upon the regulated destruction of their various proteins to maintain homeostasis and change their metabolic state. A key component of this process is the proteasome - a large multisubunit protease whose catalytic sites are sequestered within a central chamber. Entry of substrates into proteasomes is regulated by activators and is generally thought to proceed sequentially, starting ...
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Ubiquitylated substrate recognition during ubiquitin/proteasome-mediated proteolysis (UPP) is mediated directly by the proteasome subunits RPN10 and RPN13 and indirectly by ubiquitin-like (UBL) and ubiquitin-associated (UBA) domain-containing factors. To dissect the complexity and functional roles of UPP substrate recognition in Arabidopsis thaliana, potential UPP substrate receptors were chara...
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The proteasome controls the turnover of many cellular proteins. Two structural features are typically required for proteins to be degraded: covalently attached ubiquitin polypeptides that allow binding to the proteasome and an unstructured region in the targeted protein that initiates proteolysis. Here, we have tested the degradation of model proteins to further explore how the proteasome selec...
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Proteasome ATPases unravel folded proteins. Introducing a sequence containing only glycine and alanine residues (GAr) into substrates can impair their digestion. We previously proposed that a GAr interferes with the unfolding capacity of the proteasome, leading to partial degradation of products. Here we tested that idea in several ways. Stabilizing or destabilizing a folded domain within subst...
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a problem of computer vision applications is to detect regions of interest under dif- ferent imaging conditions. the state-of-the-art maximally stable extremal regions (mser) detects affine covariant regions by applying all possible thresholds on the input image, and through three main steps including: 1) making a component tree of extremal regions’ evolution (enumeration), 2) obtaining region ...
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ژورنال
عنوان ژورنال: Seibutsu Butsuri
سال: 2011
ISSN: 0582-4052,1347-4219
DOI: 10.2142/biophys.51.276